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Induced recruitment of NK cells to lymph nodes provides IFN-gamma for TH1 priming

Official URL:https://doi.org/10.1038/ni1138
PubMed:View item in PubMed
Creators Name:Martin-Fontecha, A. and Thomsen, L.L. and Brett, S. and Gerard, C. and Lipp, M. and Lanzavecchia, A. and Sallusto, F.
Journal Title:Nature Immunology
Journal Abbreviation:Nat Immunol
Volume:5
Number:12
Page Range:1260-1265
Date:1 January 2004
Keywords:Cell Differentiation, Cell Movement, Chemokine Receptors, Dendritic Cells, Immunologic Adjuvants, Interferon Type II, Natural Killer Cells, Lymph Nodes, Th1 Cells, Animals, Mice
Abstract:Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here we show in mice that natural killer (NK) cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs. Recruitment of NK cells is also induced by some, but not all, adjuvants and correlates with the induction of T helper cell type 1 (TH1) responses. NK cell depletion and reconstitution experiments show that NK cells provide an early source of interferon-γ (IFN-γ) that is necessary for TH1 polarization. Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate TH1 responses.
ISSN:1529-2908
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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