Helmholtz Gemeinschaft


Support for the involvement of TPH2 gene in affective disorders

Item Type:Letter
Title:Support for the involvement of TPH2 gene in affective disorders
Creators Name:Harvey, M. and Shink, E. and Tremblay, M. and Gagne, B. and Raymond, C. and Labbe, M. and Walther, D.J. and Bader, M. and Barden, N.
Abstract:Disturbance of the serotonergic system has been suggested as a factor in the pathogenesis of affective disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the serotonin biosynthetic pathway, and a new TPH isoform, TPH2, has been identified in the brain and localized to the long arm of chromosome 12 in a region that has been reported to contain bipolar and major depressive disorder susceptibility genes. An SNP-based association study on a case/control sample gave support to the existence of an affective disorder-associated haplotype in the TPH2 gene.
Keywords:Bipolar Disorder, Brain, Case-Control Studies, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Isoenzymes, Pair 12 Human Chromosomes, Single Nucleotide Polymorphism, Tryptophan Hydroxylase
Source:Molecular Psychiatry
Publisher:Nature Publishing Group
Page Range:980-981
Date:20 July 2004
Official Publication:https://doi.org/10.1038/sj.mp.4001557
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library