Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1

Item Type:	Article
Title:	Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
Creators Name:	Flames, N. and Long, J.E. and Garratt, A.N. and Fischer, T.M. and Gassmann, M. and Birchmeier, C. and Lai, C. and Rubenstein, J.L. and Marin, O.
Abstract:	Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified. Here, we show that different isoforms of Neuregulin-1 are expressed in the developing cortex and in the route that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4, a receptor for Neuregulin-1. The different isoforms of Neuregulin-1 act as short- and long-range attractants for migrating interneurons, and perturbing ErbB4 function in vitro decreases the number of interneurons that tangentially migrate to the cortex. In vivo, loss of Neuregulin-1/ErbB4 signaling causes an alteration in the tangential migration of cortical interneurons and a reduction in the number of GABAergic interneurons in the postnatal cortex. These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system.
Keywords:	Cell Movement, Cercopithecus Aethiops, Cerebral Cortex, COS Cells, Epidermal Growth Factor Receptor, In Situ Hybridization, Interneurons, Neuregulin-1, Protein Isoforms, Signal Transduction, Transgenic Mice, Animals, Mice
Source:	Neuron
ISSN:	0896-6273
Publisher:	Cell Press
Volume:	44
Number:	2
Page Range:	251-261
Date:	14 October 2004
Official Publication:	https://doi.org/10.1016/j.neuron.2004.09.028
PubMed:	View item in PubMed

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