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Milestones of neuronal development in the adult hippocampus

Official URL:https://doi.org/10.1016/j.tins.2004.05.013
PubMed:View item in PubMed
Creators Name:Kempermann, G. and Jessberger, S. and Steiner, B. and Kronenberg, G.
Journal Title:Trends in Neurosciences
Journal Abbreviation:Trends Neurosci
Volume:27
Number:8
Page Range:447-452
Date:1 August 2004
Keywords:Biological Markers, Vitamin D-Dependent Calcium-Binding Protein, Cell Division, Hippocampus, Neurological Models, Neuroglia, Neurons, Stem Cells, Animals, Mice
Abstract:Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.
ISSN:0166-2236
Publisher:Elsevier (The Netherlands)
Item Type:Editorial

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