Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression

Item Type:Article
Title:Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression
Creators Name:Rupp, J. and Berger, M. and Reiling, N. and Gieffers, J. and Lindschau, C. and Haller, H. and Dalhoff, K. and Maass, M.
Abstract:Peripheral blood monocytes (PBMC) promote vascular inflammation and atherosclerosis. Chlamydia pneumoniae (Cp) infection of PBMC is found in atherosclerotic patients, appears refractory to antibiotics, and may predispose to vascular damage. In Cp-infected human PBMC we analyzed the role of cyclooxygenase-2 (Cox-2) for the proatherosclerotic key mediators prostaglandin E2 (PGE2) and interstitial collagenase (MMP-1). Cp infection resulted in rapid and sustained Cox-2 mRNA and protein stimulation depending on p38 and p44/42 MAPkinases. Subsequent upregulation of PGE synthase and MMP-1 was completely abrogated by the selective Cox-2 inhibitor NS398. Enhanced synthesis of PGE2 and MMP-1 in Cp infected PBMC is mediated through initiation of the p38 and p44/42 MAPK pathways and requires sustained Cox-2 activation. Selective Cox-2 inhibitors, currently under investigation for cardiovascular risk reduction, may represent a novel therapeutic option for patients with endovascular Cp infection as they target the actuated pathological signal transduction cascade in persistently infected PBMC.
Keywords:Chlamydia pneumoniae, Infection, MAP Kinase, Cyclooxygenase, Prostaglandins, Matrix Metalloproteinases
Source:Biochemical and Biophysical Research Communications
ISSN:0006-291X
Publisher:Academic Press (U.S.A.)
Volume:320
Number:3
Page Range:738-744
Date:1 January 2004
Official Publication:https://doi.org/10.1016/j.bbrc.2004.05.210
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library