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Making tubes: Step by step

Official URL:https://doi.org/10.1016/j.devcel.2004.06.015
PubMed:View item in PubMed
Creators Name:Rosario, M. and Birchmeier, W.
Journal Title:Developmental Cell
Journal Abbreviation:Dev Cell
Volume:7
Number:1
Page Range:3-5
Date:1 July 2004
Keywords:Epithelial Cells, Hepatocyte Growth Factor, Matrix Metalloproteinases, Mitogen-Activated Protein Kinases, Mitogens, Organogenesis, Proteins, Proto-Oncogene Proteins, Growth Factor Receptors, Viscera, Animals
Abstract:Branched hollow tubes form the architectural basis of many mammalian organs. The growth factor HGF/SF and its receptor, the Met receptor tyrosine kinase, stimulate epithelial cells to undergo tubulogenesis in vitro. In this issue of Developmental Cell, O'Brien et al. (2004) look at temporal regulation and the role of two HGF/SF effectors, the ERK 1/2 MAP kinases and matrix metalloproteases, in this process.
ISSN:1534-5807
Publisher:Cell Press (U.S.A.)
Item Type:Editorial

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