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Insulin resistance in healthy prepubertal twins

Item Type:Article
Title:Insulin resistance in healthy prepubertal twins
Creators Name:Jefferies, C.A. and Hofman, P.L. and Knoblauch, H. and Luft, F.C. and Robinson, E.M. and Cutfield, W.S.
Abstract:Objectives: To evaluate insulin sensitivity (SI) in prepubertal twins and to examine the relation to reduced birth weight, prematurity, and peroxisome proliferator-activated receptor-{gamma} (PPAR{gamma}) polymorphism. Study design: Fifty twins (birth weight SDS, −0.7 ± 0.2; gestation, 33.5 ± 0.5 weeks; and body mass index SDS, −0.04 ± 0.2) were studied at 8.2 ± 0.3 years. SI was measured by Bergman's minimal model from a 90 minutes frequently sampled intravenous glucose test. Twenty control children (height SDS, −1.7 ± 0.3; birth weight SDS, −0.3 ± 0.2; and gestation of 39.2 ± 0.7 weeks) were also evaluated at 7.0 ± 0.4 years. The PPAR{gamma} T-variant polymorphism was evaluated in 41 twins. Values are expressed as mean ± SEM, or 95% confidence intervals. Results: SI was reduced in twins compared with control subjects, (12.7 [11-15] versus 23.0 [16.8-31.4] 10−4 min−1 {my}U/mL, respectively, P = .005). The reduction in SI was independent of prematurity and birth weight and zygosity (P<.0001). There was no difference in SI, even in twin pairs with >20% difference in birth weight (P = .9). The PPAR{gamma} heterozygote T-variant polymorphism was present in 7 of 41, with a further reduction in SI (P = .03) and a later gestation (P = .03). These twins also had increased fat mass (P = .02) but with similar fat free mass (P = .14). Conclusions: Twin children, independent of prematurity or birth weight, had a marked reduction in SI. To use twins as a model to study the fetal origins of adult diseases for glucose homeostasis is not valid.
Keywords:Case-Control Studies, Cytoplasmic and Nuclear Receptors, Diseases in Twins, Genetic Polymorphism, Insulin Resistance, Low Birth Weight Infant, New Zealand, Premature Infant, Transcription Factors, Type 2 Diabetes Mellitus
Source:Journal of Pediatrics
Page Range:608-613
Date:May 2004
Official Publication:https://doi.org/10.1016/j.jpeds.2004.01.059
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