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Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development

Item Type:Article
Title:Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development
Creators Name:Petersen, H.H. and Hilpert, J. and Jacobsen, C. and Lauwers, A. and Roebroek, A.J.M. and Willnow, T.E.
Abstract:The intracellular domain (ICD) of the low-density lipoprotein receptor-related protein (LRP) functionally interacts with adaptor proteins both as an integral part of the receptor polypeptide and after proteolytic release. Identification of such adaptors has been difficult because the ICD is self-activating in conventional transcription factor-based yeast two-hybrid screens. We adopted an alternative screen for the ICD that depends on the activation of the Ras-signaling pathway and uncovered the transcription factor MafB as novel ICD interacting protein. MafB is a regulator of hindbrain segmentation and interacts with the ICD through a leucine zipper domain. The ICD co-localizes with MafB to the nucleus and negatively regulates its transcriptional activity, suggesting a possible role for LRP in brain development.
Keywords:Intracellular Domain, Kreisler, Leucine Zipper Domain, Low-density Lipoprotein Receptor Gene Family, Transcription Factor, Yeast Two-Hybrid Screen, Animals, Mice
Source:FEBS Letters
ISSN:0014-5793
Publisher:Elsevier (The Netherlands)
Volume:565
Number:1-3
Page Range:23-27
Date:1 January 2004
Official Publication:https://doi.org/10.1016/j.febslet.2004.03.069
PubMed:View item in PubMed

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