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Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation

Item Type:Article
Title:Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation
Creators Name:Knosalla, C. and Mueller, J. and Moran, K. and Wallukat, G. and Hetzer, R. and Cooper, D.K.C.
Abstract:We assessed the efficiency of non-specific extracorporeal immunoadsorption (EIA), using polyclonal anti-human immunoglobulin antibodies, in depleting the serum of anti-galactose{alpha}1,3galactose (Gal) antibody and in decreasing serum cytotoxicity in 5 patients with idiopathic dilated cardiomyopathy. The mean concentrations of anti-Gal immunoglobulin (Ig)M and IgG before EIA were 74 μg/ml and 159 μg/ml, respectively. After EIA, these concentrations decreased by 86% and 88%, respectively. Both anti-Gal IgM and IgG returned to pre-EIA concentrations within 1 month, without rebound to greater than baseline concentrations. After EIA, mean serum cytotoxicity also decreased from 90% to 17%, with recovery by 1 month. Extracorporeal immunoadsorption proved safe in patients with heart failure and was effective in depleting anti-Gal antibody and in decreasing serum cytotoxicity to pig cells.
Keywords:Anti-Idiotypic Antibodies, Autoantibodies, Dilated Cardiomyopathy, Disaccharides, Heart, Heart Transplantation, Immunoglobulin G, Immunoglobulin M, Immunosorbent Techniques, Myocardium, Heterologous Transplantation, Animals, Swine
Source:Journal of Heart and Lung Transplantation
ISSN:1053-2498
Publisher:Elsevier Science Inc (U.S.A.)
Volume:23
Number:5
Page Range:623-626
Date:May 2004
Official Publication:https://doi.org/10.1016/S1053-2498(03)00229-8
PubMed:View item in PubMed

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