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Axonal neuregulin-1 regulates myelin sheath thickness

Official URL:https://doi.org/10.1126/science.1095862
PubMed:View item in PubMed
Creators Name:Michailov, G.V. and Sereda, M.W. and Brinkmann, B.G. and Fischer, T.M. and Haug, B. and Birchmeier, C. and Role, L. and Lai, C. and Schwab, M.H. and Nave, K.A.
Journal Title:Science
Journal Abbreviation:Science
Volume:304
Number:5671
Page Range:700-703
Date:30 April 2004
Keywords:Axons, Spinal Ganglia, Gene Targeting, erbB Genes, erbB-2 Genes, Heterozygote, Neurological Models, Myelin Sheath, Neural Conduction, Neuregulin-1, Protein Isoforms, Epidermal Growth Factor Receptor, erbB-2 Receptor, erbB-3 Receptor, Schwann Cells, Sciatic Nerve, Signal Transduction, Animals, Mice
Abstract:In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size.
ISSN:0036-8075
Publisher:American Association for the Advancement of Science (U.S.A.)
Item Type:Article

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