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Optimierung des Staging beim Kolonkarzinom durch Sentinel-Lymphknoten-Biopsie. Aktuelle Aspekte [Optimization of staging in colon cancer using sentinel lymph node biopsy]

Item Type:Article
Title:Optimierung des Staging beim Kolonkarzinom durch Sentinel-Lymphknoten-Biopsie. Aktuelle Aspekte [Optimization of staging in colon cancer using sentinel lymph node biopsy]
Creators Name:Bembenek, A. and Schneider, U. and Gretschel, S. and Ulmer, C. and Schlag, P.M.
Abstract:Routine determination of the nodal status in colon cancer is strongly dependent on the individual quality and technique of histopathological assessment and surgical lymph node dissection. We evaluated whether sentinel lymph node biopsy (SLNB) could contribute to an improvement in staging. At least one SLN (median n=2) was detected (detection rate 84%) in each of 38 of 45 patients with primary colon cancer. Ten of these 38 were found to have lymph node metastases by HE staining (26%), six of them in the SLN. Nine of the 28 patients that were initially nodal-negative by HE revealed one micrometastasis and eight cases of isolated tumor cells by immunohistochemical (IHC) staining (32% upstaging response). Including the IHC-positive cases, 19 of the 38 patients were nodal-positive (50%), 15 of them with tumor-infiltrated SLN (overall sensitivity of SLNB 79%). Using the dye method, SLNB is clinically practicable and leads in the majority of the patients to the detection of SLN. The selective, intensified histopathological assessment of SLN identifies small tumor cell deposits in a relevant percentage of patients with little and clinically practicable effort.
Keywords:Colon Carcinoma, Sentinel Lymph Node Biopsy, Lymph Node Staging, Staining Method, Histopathological Workup
Source:Chirurg
ISSN:0009-4722
Publisher:Springer (Germany)
Volume:76
Number:1
Page Range:58-67
Date:January 2005
Official Publication:https://doi.org/10.1007/s00104-004-0820-1
PubMed:View item in PubMed

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