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LRP and PDGF signaling: a pathway to atherosclerosis

Item Type:Review
Title:LRP and PDGF signaling: a pathway to atherosclerosis
Creators Name:Boucher, P. and Gotthardt, M.
Abstract:The low-density lipoprotein (LDL) receptor-related protein (LRP) is a member of the LDL receptor family. In addition to its role in endocytosis and uptake of multiple ligands, it is now apparent that LRP, like some other members of the family, is also involved in signal transduction. Through LRP, both endocytosis and signaling coexist at the surface of the plasma membrane and regulate critical cellular physiology and signal transduction events. This article focuses on the recently uncovered molecular mechanisms by which LRP, its ligand apolipoprotein E, and the platelet-derived growth factor receptor cooperate in the remodeling of the vascular wall and protect against atherosclerosis.
Keywords:Apolipoproteins E, Arteriosclerosis, Endocytosis, LDL-Receptor Related Protein 1, Membrane Glycoproteins, Multigene Family, Platelet-Derived Growth Factor Receptors, Signal Transduction, Animals
Source:Trends in Cardiovascular Medicine
Page Range:55-60
Date:February 2004
Official Publication:https://doi.org/10.1016/j.tcm.2003.12.001
PubMed:View item in PubMed

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