Helmholtz Gemeinschaft


Global analysis of bacterial transcription factors to predict cellular target processes

Official URL:https://doi.org/10.1016/j.tig.2004.01.006
PubMed:View item in PubMed
Creators Name:Doerks, T. and Andrade, M.A. and Lathe, W. and von Mering, C. and Bork, P.
Journal Title:Trends in Genetics
Journal Abbreviation:Trends Genet
Page Range:126-131
Date:1 January 2004
Keywords:Bacteria, Bacterial Genes, Bacterial Genome, Computational Biology, Conserved Sequence, Databases, Gene Order, Genomics, Multigene Family, Phylogeny, Transcription Factors
Abstract:Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs.
Publisher:Elsevier (The Netherlands)
Item Type:Article

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