Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Global analysis of bacterial transcription factors to predict cellular target processes

Item Type:Article
Title:Global analysis of bacterial transcription factors to predict cellular target processes
Creators Name:Doerks, T. and Andrade, M.A. and Lathe, W. and von Mering, C. and Bork, P.
Abstract:Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs.
Keywords:Bacteria, Bacterial Genes, Bacterial Genome, Computational Biology, Conserved Sequence, Databases, Gene Order, Genomics, Multigene Family, Phylogeny, Transcription Factors
Source:Trends in Genetics
ISSN:0168-9525
Publisher:Elsevier (The Netherlands)
Volume:20
Number:3
Page Range:126-131
Date:1 January 2004
Official Publication:https://doi.org/10.1016/j.tig.2004.01.006
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library