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The nature and identification of quantitative trait loci: a community's view

Item Type:Review
Title:The nature and identification of quantitative trait loci: a community's view
Creators Name:Abiola, O. and Angel, J.M. and Avner, P. and Bachmanov, A.A. and Belknap, J.K. and Bennett, B. and Blankenhorn, E.P. and Blizard, D.A. and Bolivar, V. and Brockmann, G.A. and Buck, K.J. and Bureau, J.F. and Casley, W.L. and Chesler, E.J. and Cheverud, J.M. and Churchill, G.A. and Cook, M. and Crabbe, J.C. and Crusio, W.E. and Darvasi, A. and de Haan, G. and Dermant, P. and Doerge, R.W. and Elliot, R.W. and Farber, C.R. and Flaherty, L. and Flint, J. and Gershenfeld, H. and Gibson, J.P. and Gu, J. and Gu, W. and Himmelbauer, H. and Hitzemann, R. and Hsu, H.C. and Hunter, K. and Iraqi, F.F. and Jansen, R.C. and Johnson, T.E. and Jones, B.C. and Kempermann, G. and Lammert, F. and Lu, L. and Manly, K.F. and Matthews, D.B. and Medrano, J.F. and Mehrabian, M. and Mittlemann, G. and Mock, B.A. and Mogil, J.S. and Montagutelli, X. and Morahan, G. and Mountz, J.D. and Nagase, H. and Nowakowski, R.S. and O'Hara, B.F. and Osadchuk, A.V. and Paigen, B. and Palmer, A.A. and Peirce, J.L. and Pomp, D. and Rosemann, M. and Rosen, G.D. and Schalkwyk, L.C. and Seltzer, Z. and Settle, S. and Shimomura, K. and Shou, S. and Sikela, J.M. and Siracusa, L.D. and Spearow, J.L. and Teuscher, C. and Threadgill, D.W. and Toth, L.A. and Toye, A.A. and Vadasz, C. and Van Zant, G. and Wakeland, E. and Williams, R.W. and Zhang, H.G. and Zou, F.
Abstract:This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?
Keywords:Chromosome Mapping, Genetically Modified Animals, Quantitative Trait Loci, Animals
Source:Nature Reviews Genetics
ISSN:1471-0056
Publisher:Nature Publishing Group (U.S.A.)
Volume:4
Number:11
Page Range:911-916
Date:1 November 2003
Official Publication:https://doi.org/10.1038/nrg1206
PubMed:View item in PubMed

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