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Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10

Item Type:Article
Title:Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10
Creators Name:Monti, J. and Plehm, R. and Schulz, H. and Ganten, D. and Kreutz, R. and Huebner, N.
Abstract:We have used inbred and congenic rat strains in F2 segregation studies to discover epistasis in a polygenic model of hypertension. Previously, we have found evidence that the presence of a blood pressure quantitative trait locus (QTL) on chromosome 1 is conditional upon the allele status of chromosome 10. To prove the existence of an epistatic interaction we have analyzed congenic strains for chromosome 1 and 10 carrying high blood pressure QTL alleles from the spontaneously hypertensive rat on a normotensive background of the Wistar–Kyoto (WKY) rat. Additionally, a double congenic strain was developed with both chromosome 1 and 10 high blood pressure QTL alleles on the WKY background. Analysis of variance for blood pressure phenotypes as determined by radiotelemetry showed a significant effect for chromosome 10 but not chromosome 1 QTL alleles and demonstrated a significant interaction between the two loci (P<0.05). The interaction accounted for 5 mmHg of blood pressure. Thus, the identification of epistasis is critical to the understanding of the quantitative nature of blood pressure genetics.
Keywords:Alleles, Analysis of Variance, Animal Disease Models, Blood Pressure, Chromosome Mapping, Genetic Epistasis, Genetic Models, Genotype, Hypertension, Inbred WKY Rats, Phenotype, Quantitative Trait Loci, Animals, Rats
Source:Human Molecular Genetics
ISSN:0964-6906
Publisher:Oxford University Press (U.K.)
Volume:12
Number:4
Page Range:435-439
Date:1 January 2003
Official Publication:https://doi.org/10.1093/hmg/ddg041
PubMed:View item in PubMed

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