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Lipoprotein and receptor interactions in vivo

Item Type:Review
Title:Lipoprotein and receptor interactions in vivo
Creators Name:Herz, J. and Willnow, T.E.
Abstract:A substantial number of animal models aimed at the genetic dissection of lipid metabolism have been generated recently. Transgenic and knockout mice, in which the receptors or apolipoproteins are overexpressed or destroyed, combined with virus-mediated gene transfer in vivo have advanced our understanding of the complex physiological and pathophysiological processes involved in lipid metabolism, including hepatic lipoprotein uptake and the formation of atherosclerotic lesions.
Keywords:Apolipoproteins E, Lipoproteins, Knockout Mice, Transgenic Mice, Proteoglycans, LDL Receptors, Lipoprotein Receptors, Animals, Mice
Source:Current Opinion in Lipidology
ISSN:0957-9672
Publisher:Lippincott, Williams & Wilkins (U.S.A.)
Volume:6
Number:2
Page Range:97-103
Date:April 1995
PubMed:View item in PubMed

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