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Modularity in the gain and loss of genes: applications for function prediction

Item Type:Editorial
Title:Modularity in the gain and loss of genes: applications for function prediction
Creators Name:Ettema, T. and van der Oost, J. and Huynen, M.
Abstract:Genes that are clustered on multiple genomes and are likely to functionally interact tend to be gained or lost together during genome evolution. Here, we demonstrate that exceptions to this pattern indicate relatively distant functional interactions between the encoded proteins. Hence, this can be used to divide predicted clusters of functionally interacting proteins into sub-clusters, and as such, to refine the prediction of their function and functional interactions.
Keywords:Functional Coupling of Genes, Gene Loss, Gene Gain, Evolution, Gene Cluster, Genome Modularity, Genetics
Source:Trends in Genetics
ISSN:0168-9525
Publisher:Elsevier (The Netherlands)
Volume:17
Number:9
Page Range:485-487
Date:September 2001
Official Publication:https://doi.org/10.1016/S0168-9525(01)02384-8
PubMed:View item in PubMed

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