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β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Item Type:Article
Title:β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Creators Name:Morkel, M. and Huelsken, J. and Wakamiya, M. and Ding, J. and van de Wetering, M. and Clevers, H. and Taketo, M.M. and Behringer, R.R. and Shen, M.M. and Birchmeier, W.
Abstract:Gene expression profiling of {beta}-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by {beta}-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of {beta}-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/{beta}-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to {beta}-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.
Keywords:Anteroposterior Axis, Gastrulation, Microarray, Nanog, Signalling Pathways, Tdgf1, Animals, Mice
Source:Development
ISSN:0950-1991
Publisher:Company of Biologists (U.K.)
Volume:130
Number:25
Page Range:6283-6294
Date:1 January 2003
Official Publication:https://doi.org/10.1242/dev.00859
PubMed:View item in PubMed

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