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Met, metastasis, motility and more

Official URL:https://doi.org/10.1038/nrm1261
PubMed:View item in PubMed
Creators Name:Birchmeier, C. and Birchmeier, W. and Gherardi, E. and Vande Woude, G.F.
Journal Title:Nature Reviews Molecular Cell Biology
Journal Abbreviation:Nat Rev Mol Cell Biol
Volume:4
Number:12
Page Range:915-925
Date:December 2003
Keywords:Binding Sites, Cell Line, Cell Movement, Cell Size, Hepatocyte Growth Factor, Intracellular Signaling Peptides and Proteins, Molecular Models, Morphogenesis, Neoplasm Metastasis, Neoplasms, Phosphoproteins, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Protein Tyrosine Phosphatases, Proto-Oncogene Proteins c-met, Signal Transduction, Animals, Mice, Caenorhabditis Elegans , Drosophila Melanogaster
Abstract:Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 — homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster — for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.
ISSN:1471-0072
Publisher:Nature Publishing Group (U.K.)
Item Type:Review

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