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Radiochemotherapie plus Hyperthermie beim Rektumkarzinom

Item Type:Article
Title:Radiochemotherapie plus Hyperthermie beim Rektumkarzinom
Creators Name:Rau, B. and Wust, P. and Riess, H. and Schlag, P.M.
Abstract:In locally advanced rectal cancer (uT3/uT4) resectability as well as local control is reduced. In the patients combined preoperative radiochemotherapy demonstrated an increase of resectability and a reduction of local recurrence. Radiotherapy was applied in standard blocks, 5X 1,8 Gy up to 45 Gy. Chemotherapy consisted out of two cycles of 5-Fluorouracil (300-350 mg/m2/d) and Leucovorin (50 mg). Prior to radiotherapy additionally therrnotherapy was carried out using the SIGMA 60 applicator BSD 2000 once a week. The hyperthermia method is based on heating up affected tissue compartments to temperature above 42 degrees Celsius without damaging surrounding tissue compartments. In regional hyperthermia tumors in the abdominal region are treated by emitting radio waves into the patient. 4-6 weeks after radiochemotherapy, surgery was perforrned. The therapeutic toxicity was acceptable and the resectability rate was up to 90%. Response rate to treatment was 60%. Our data with preoperative combined treatment in locally advanced rectal cancer revealed encouraging downstaging, local control, and survival rates.
Keywords:Rectal Cancer, Hyperthermia, Radio-Chemotherapy, Neoadjuvant Therapy, Preoperative Therapy
Source:Schweizerische Rundschau fuer Medizin Praxis
Page Range:587-592
Date:5 April 2001
PubMed:View item in PubMed

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