Helmholtz Gemeinschaft


Therapeutische Strategien bei malignen Weichteiltumoren : Ergebnisse der Weichteiltumor-Registerstudie der CAO

Item Type:Article
Title:Therapeutische Strategien bei malignen Weichteiltumoren : Ergebnisse der Weichteiltumor-Registerstudie der CAO
Creators Name:Junginger, T. and Kettelhack, C. and Schoenfelder, M. and Saeger, H.D. and Rieske, H. and Krummenauer, F. and Hermanek, P.
Abstract:Introduction: This study, carried out by the Surgical Oncology Working Group (CAO) of the German Society for Surgery, was performed to analyse the strategies in the treatment of soft tissue sarcomas in adults. Methods: In a period of 19 months the data on 292 patients suffering from soft tissue sarcomas, treated in 99 surgical departments in Germany, were analysed prospectively. A special questionnaire was developed including pretherapeutic biopsy, previous treatment, definitive surgical treatment, combined modality approach and histopathological results. Results: Thirty-nine per cent of the tumours were treated in university hospitals, 36 % in medical centres, 24 % in regional hospitals. During the observation period two patients were treated on average (median) by each hospital. Limb-sparing treatment was performed in 96 % of the extremity tumours. There was no significant difference in the frequency of R0 resections between the different hospitals. At the university hospitals local extended operations and additive measures were used more often. The indication for adjuvant radiotherapy differed: after compartmental resection, adjuvant radiotherapy was performed in 39 % of cases (19/49); after wide-excision of high-grade tumours, in 45 % of cases (20/44) no adjuvant radiotherapy was necessary. In spite of less radical treatment in tumours of the trunk, additional radiotherapy was not more frequently performed. Conclusion: To improve the quality in the treatment of soft tissue sarcomas it seems to be of great importance to avoid inadequate initial treatment (18 %), to respect the rules of oncological surgery (tumour rupture in 7 % of cases), to improve the histopathological examination (no R classification in 5–12 %) and to develop guidelines for multimodality treatment.
Keywords:Soft Tissue Sarcoma, Therapy, Register Study
Page Range:138-148
Date:February 2001
Official Publication:https://doi.org/10.1007/s001040051281
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library