Adult-born hippocampal neurons mature into activity-dependent responsiveness

Item Type:	Article
Title:	Adult-born hippocampal neurons mature into activity-dependent responsiveness
Creators Name:	Jessberger, S. and Kempermann, G.
Abstract:	The mammalian hippocampus is a highly plastic brain structure in which new neurons are generated throughout adulthood. Do these new neurons qualitatively and quantitatively participate in the activity-dependent gene expression after challenging the hippocampus in a learning task? Adult mice were injected with bromodeoxyuridine (BrdU) to label dividing cells and indeed, individual BrdU-labelled new neurons expressed the immediate early gene protein (IEGp) c-fos during the acquisition phase of the Morris water maze task to the same extend as older granule cells. To assess the responsiveness of all new neurons we also analysed the expression patterns of three IEGps (c-fos, zif268 and Homer1A) after kainic acid (KA)- or pentylenetetrazol (PTZ)-induced seizures. We found that after a maturation period of between 2 and 5 weeks a comparable ratio of adult-generated granule cells participated in IEGp-expression as in the population of older granule cells. Thus, new neurons appear quantitatively integrated into hippocampal circuits, suggestive of a relevant contribution to hippocampal function.
Keywords:	BrdU, Hippocampus, IEG, Neurogenesis, Stem cell, Animals, Mice
Source:	European Journal of Neuroscience
ISSN:	0953-816X
Publisher:	Blackwell Publishing
Volume:	18
Number:	10
Page Range:	2707-2712
Date:	1 January 2003
Official Publication:	https://doi.org/10.1111/j.1460-9568.2003.02986.x
PubMed:	View item in PubMed

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