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Role of {beta}-catenin in synaptic vesicle localization and presynaptic assembly

Item Type:Article
Title:Role of {beta}-catenin in synaptic vesicle localization and presynaptic assembly
Creators Name:Bamji, S.X. and Shimazu, K. and Kimes, N. and Huelsken, J. and Birchmeier, W. and Lu, B. and Reichardt, L.F.
Abstract:Cadherins and catenins are thought to promote adhesion between pre and postsynaptic elements in the brain. Here we show a role for {beta}-catenin in localizing the reserved pool of vesicles at presynaptic sites. Deletion of {beta}-catenin in hippocampal pyramidal neurons in vivo resulted in a reduction in the number of reserved pool vesicles per synapse and an impaired response to prolonged repetitive stimulation. This corresponded to a dispersion of vesicles along the axon in cultured neurons. Interestingly, these effects are not due to {beta}-catenin's involvement in cadherin-mediated adhesion or wnt signaling. Instead, {beta}-catenin modulates vesicle localization via its PDZ binding domain to recruit PDZ proteins such as Veli to cadherin at synapses. This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion.
Keywords:Beta Catenin, Cadherins, Carrier Proteins, Cultured Cells, Cytoskeletal Proteins, Electric Stimulation, Electron Microscopy, Fetus, Presynaptic Terminals, Pyramidal Cells, Synaptic Membranes, Synaptic Transmission, Synaptic Vesicles, Tertiary Protein Structure, Trans-Activators, Transgenic Mice, Animals, Mice, Rats
Source:Neuron
ISSN:0896-6273
Publisher:Cell Press (U.S.A.)
Volume:40
Number:4
Page Range:719-731
Date:November 2003
Official Publication:https://doi.org/10.1016/S0896-6273(03)00718-9
PubMed:View item in PubMed

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