Deletion of beta-catenin impairs T cell development

Item Type:	Article
Title:	Deletion of beta-catenin impairs T cell development
Creators Name:	Xu, Y. and Banerjee, D. and Huelsken, J. and Birchmeier, W. and Sen, J.M.
Abstract:	T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the {alpha}{beta} TCR. Here we show that T cell-specific deletion of {beta}-catenin impaired T cell development at the {beta}-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, {beta}-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that {beta}-catenin-mediated signals are required for normal T cell development.
Keywords:	Beta Catenin, Cell Differentiation, Cellular Immunity, Cytoskeletal Proteins, Flow Cytometry, Gene Deletion, Immune System, Polymerase Chain Reaction, Spleen, T-Cell Antigen Receptors, T-Lymphocytes, Trans-Activators, Transgenic Mice, Animals, Mice
Source:	Nature Immunology
ISSN:	1529-2908
Publisher:	Nature Publishing Group
Volume:	4
Number:	12
Page Range:	1177-1182
Date:	1 January 2003
Official Publication:	https://doi.org/10.1038/ni1008
PubMed:	View item in PubMed

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