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Deletion of beta-catenin impairs T cell development

Official URL:https://doi.org/10.1038/ni1008
PubMed:View item in PubMed
Creators Name:Xu, Y. and Banerjee, D. and Huelsken, J. and Birchmeier, W. and Sen, J.M.
Journal Title:Nature Immunology
Journal Abbreviation:Nat Immunol
Volume:4
Number:12
Page Range:1177-1182
Date:1 January 2003
Keywords:Beta Catenin, Cell Differentiation, Cellular Immunity, Cytoskeletal Proteins, Flow Cytometry, Gene Deletion, Immune System, Polymerase Chain Reaction, Spleen, T-Cell Antigen Receptors, T-Lymphocytes, Trans-Activators, Transgenic Mice, Animals, Mice
Abstract:T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the {alpha}{beta} TCR. Here we show that T cell-specific deletion of {beta}-catenin impaired T cell development at the {beta}-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, {beta}-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that {beta}-catenin-mediated signals are required for normal T cell development.
ISSN:1529-2908
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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