Helmholtz Gemeinschaft


Smooth, slow and smart muscle motors

Item Type:Article
Title:Smooth, slow and smart muscle motors
Creators Name:Arner, A. and Loefgren, M. and Morano, I.
Abstract:Smooth muscle is a slow and economical muscle with a large variability in contractile properties. This review describes results regarding the relation between expression of myosin isoforms and the contraction of smooth muscle. The focus of the review is on studies of the organised contractile system in the smooth muscle tissue. The role of the myosin heavy chain variants formed by alternative splicing in the myosin heavy chain tail (SM1, SM2 isoforms) and head (SM-A SM-B isoforms) regions, as well as the role of essential light chains (LC17a, LC17b isoforms) for the variability of contractile properties are discussed. Smooth muscle also has the ability to alter its contractile properties in response to altered functional demands in vivo, e.g. during hypertrophic growth of urinary bladder, intestine, uterus and vessels and in response to altered hormone levels. These alterations involve changes in myosin expression and altered contractile kinetics. Non-muscle myosin has been shown to have a contractile function in some smooth muscle tissues and recent data on the kinetic properties of non-muscle myosin filaments in smooth muscle tissue are described.
Keywords:Adenosine Triphosphate, Fast-Twitch Muscle Fibers, Gene Expression Regulation, Kinetics, Molecular Motor Proteins, Muscle Contraction, Myosin Heavy Chains, Nonmuscle Myosin Type IIB, Protein Isoforms, Slow-Twitch Muscle Fibers, Smooth Muscle, Smooth Muscle Myosins, Animals
Source:Journal of Muscle Research and Cell Motility
Page Range:165-173
Date:April 2003
Official Publication:https://doi.org/10.1023/A:1026001513928
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library