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Genetic interaction between Wnt/{beta}-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

Official URL:https://doi.org/10.1101/gad.263003
PubMed:View item in PubMed
Creators Name:Soshnikova, N. and Zechner, D. and Huelsken, J. and Mishina, Y. and Behringer, R.R. and Taketo, M.M. and Crenshaw, E.B. and Birchmeier, W.
Journal Title:Genes & Development
Journal Abbreviation:Genes Dev
Page Range:1963-1968
Date:1 January 2003
Keywords:Engrailed-1, FGF, Frizzled, Limb Ventral Ectoderm, Proximal-Distal Axis, Animals, Mice
Abstract:By conditional gene ablation in mice, we found that {beta}-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that {beta}-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/{beta}-catenin and BMP receptor signaling.
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Item Type:Article

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