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Functional and structural characterization of anti-β1-adrenoceptor autoantibodies of spontaneously hypertensive rats

Item Type:Article
Title:Functional and structural characterization of anti-β1-adrenoceptor autoantibodies of spontaneously hypertensive rats
Creators Name:Wallukat, G. and Podlowski, S. and Nissen, E. and Morwinski, R. and Csonka, C. and Tosaki, A. and Blasig, I.E.
Abstract:Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the {beta} 1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the {beta} 1,-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the {beta} 1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-{beta} 1-adrenoceptor antibodies in the induction of human cardiomyopathy
Keywords:{beta}1-Adrenoceptor, Autoantibodies, Spontaneously Hypertensive Rats, Heart Failure, Cardiomyocytes, Animals, Rats
Source:Molecular and Cellular Biochemistry
ISSN:0300-8177
Publisher:Springer (Germany)
Volume:251
Number:1-2
Page Range:67-75
Date:September 2003
Official Publication:https://doi.org/10.1023/A:1025469515963
PubMed:View item in PubMed

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