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Peptide based adsorbers for therapeutic immunoadsorption

Item Type:Article
Title:Peptide based adsorbers for therapeutic immunoadsorption
Creators Name:Roenspeck, W. and Brinckmann, R. and Egner, R. and Gebauer, F. and Winkler, D. and Jekow, P. and Wallukat, G. and Mueller, J. and Kunze, R.
Abstract:Peptides as ligands for immunoadsorption exhibit several potentialadvantages over native proteins. Two newly developed adsorbers arebased on peptides covalently coupled to sepharose CL-4B. Globaffinis capable of binding immunoglobulins independent from their antigenspecificity and thus, applicable in transplant recipients and severalantibody mediated autoimmune diseases. Among others, the most importantdisorders suitable for the treatment with Globaffin are rheumatoidarthritis, systemic lupus erythematosus, and acute renal transplant rejection.Coraffin is a specific adsorber using two linear peptide ligandsmimicking epitopes of the {beta}(1)-adrenergic receptor,that bind corresponding autoantibodies from patients suffering fromidiopathic dilated cardiomyopathy. Specific immunoadsorption hasbeen shown to be beneficial for patients with dilated cardiomyopathy. Coraffin can be used as a new therapeutic option for these patients, who get only limited benefit from medicaltherapy. Both adsorbers may be combined with all approved apheresis control devices available.
Keywords:Apheresis, Autoantibodies, Autoimmunity, Epitopes, Immunoglobulins, Immunoadsorption, Protein-A
Source:Therapeutic Apheresis
Page Range:91-97
Date:February 2003
Official Publication:https://doi.org/10.1046/j.1526-0968.2003.00017.x
PubMed:View item in PubMed

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