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Tonin in rat heart with experimental hypertrophy

Item Type:Article
Title:Tonin in rat heart with experimental hypertrophy
Creators Name:Borges, J.C. and Silva, J.A. and Gomes, M.A. and Lomez, E.S.L. and Leite, K.M. and Araujo, R.C. and Bader, M. and Pesquero, J.B. and Pesquero, J.L.
Abstract:The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg·kg -1·day -1 sc). For untreated animals, the levels of tonin-specific activity in the atrium were 2.6- and 5.5-fold higher than those of the left and right ventricle, respectively. After treatment, the levels of tonin-specific activity increased twofold in the atrium but did not change in the ventricles. Renin expression was not detectable in these structures, and ACE expression levels did not change with treatment. AG expression was detected in the left ventricle at very low levels compared with the atrium and increased significantly only in the hypertrophied atrium (1.8-fold). Tonin mRNA was not detected in the ventricle but was found at low levels in the atrium, which increased after isoproterenol treatment. Our results permit us to conclude that tonin may play a role in the process of heart hypertrophy in the rat.
Keywords:Angiotensin II, Angiotensinogen, Growth Myocardium, Isoproterenol, Renin, Animals, Rats
Source:American Journal of Physiology Heart and Circulatory Physiology
ISSN:0363-6135
Publisher:American Physiological Society (U.S.A.)
Volume:284
Number:6
Page Range:H2263-H2268
Date:1 June 2003
Official Publication:https://doi.org/10.1152/ajpheart.00416.2002
PubMed:View item in PubMed

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