Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

Item Type:	Article
Title:	Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence
Creators Name:	Franke, P. and Wendel, B. and Knapp, M. and Schwab, S.G. and Neef, D. and Maier, W. and Wildenauer, D.B. and Hoehe, M.R.
Abstract:	Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human μ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. - In contrast to classical case-control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results. - For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. - Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case-control association studies of opioid dependent individuals.
Keywords:	Addiction, Case-Control Study, Opioids, OPRM1, Polymorphism
Source:	European Psychiatry
ISSN:	0924-9338
Publisher:	Editions Scientifiques Medicales Elsevier
Volume:	18
Number:	1
Page Range:	18-22
Date:	1 February 2003
Official Publication:	https://doi.org/10.1016/S0924-9338(02)00005-6
PubMed:	View item in PubMed

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