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The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia

Item Type:Article
Title:The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia
Creators Name:Ciccarelli, F.D. and Proukakis, C. and Patel, H. and Cross, H. and Azam, S. and Patton, M.A. and Bork, P. and Crosby, A.H.
Abstract:Multiple sequence alignment has revealed the presence of a sequence domain of ∼80 amino acids in two molecules, spartin and spastin, mutated in hereditary spastic paraplegia. The domain, which corresponds to a slightly extended version of the recently described ESP domain of unknown function, was also identified in VPS4, SKD1, RPK118, and SNX15, all of which have a well established and consistent role in endosomal trafficking. Recent functional information indicates that spastin is likely to be involved in microtubule interaction. With this new information relating to its likely function, we propose the more descriptive name 'MIT' (contained within microtubule-interacting and trafficking molecules) for the domain and predict endosomal trafficking as the principal functionality of all molecules in which it is present.
Keywords:Adenosine Triphosphatases, Amino Acid Sequence, Calcium-Binding Proteins, Endosomes, Hereditary Spastic Paraplegia, Molecular Evolution, Proteins, Sequence Alignment, Tertiary Protein Structure
Source:Genomics
ISSN:0888-7543
Publisher:Academic Press
Volume:81
Number:4
Page Range:437-441
Date:April 2003
Official Publication:https://doi.org/10.1016/S0888-7543(03)00011-9
PubMed:View item in PubMed

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