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Translational control of SCL-isoform expression in hematopoietic lineage choice

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Official URL:https://doi.org/10.1101/gad.251903
PubMed:View item in PubMed
Creators Name:Calkhoven, C.F. and Mueller, C. and Martin, R. and Krosl, G. and Hoang, T. and Leutz, A.
Journal Title:Genes & Development
Journal Abbreviation:Genes Dev
Page Range:959-964
Date:15 April 2003
Keywords:EIF2{alpha}, EIF4E, Hematopoiesis, Lineage commitment, Translation Initiation, UORF, Animals, Cricetinae
Abstract:We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice. We show that the expression of different SCL protein isoforms is regulated by signal transduction pathways that modulate translation initiation factor (eIF) function. A conserved small upstream open reading frame (uORF) in SCL transcripts acts as a cis-regulatory element for isoform expression. At the onset of erythroid differentiation, truncated SCL protein isoforms arise by alternative translation initiation and favor the erythroid lineage. In comparison, full-length SCL proteins are more efficient at enhancing the megakaryocyte lineage. Together, our studies unravel translational control as a novel mechanism regulating hematopoietic outcome.
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Item Type:Article

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