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Translational control of SCL-isoform expression in hematopoietic lineage choice

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Item Type:Article
Title:Translational control of SCL-isoform expression in hematopoietic lineage choice
Creators Name:Calkhoven, C.F. and Mueller, C. and Martin, R. and Krosl, G. and Hoang, T. and Leutz, A.
Abstract:We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice. We show that the expression of different SCL protein isoforms is regulated by signal transduction pathways that modulate translation initiation factor (eIF) function. A conserved small upstream open reading frame (uORF) in SCL transcripts acts as a cis-regulatory element for isoform expression. At the onset of erythroid differentiation, truncated SCL protein isoforms arise by alternative translation initiation and favor the erythroid lineage. In comparison, full-length SCL proteins are more efficient at enhancing the megakaryocyte lineage. Together, our studies unravel translational control as a novel mechanism regulating hematopoietic outcome.
Keywords:EIF2{alpha}, EIF4E, Hematopoiesis, Lineage commitment, Translation Initiation, UORF, Animals, Cricetinae
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Volume:17
Number:8
Page Range:959-964
Date:15 April 2003
Official Publication:https://doi.org/10.1101/gad.251903
PubMed:View item in PubMed

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