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Prognoserelevanz von biologischen und molekularen Markern in der Onkologie : Kriterien fur Studienplanung und -Interpretation. [Prognostic relevance of biological and molecular markers in oncology. Criteria for planning and interpreting studies]

Item Type:Article
Title:Prognoserelevanz von biologischen und molekularen Markern in der Onkologie : Kriterien fur Studienplanung und -Interpretation. [Prognostic relevance of biological and molecular markers in oncology. Criteria for planning and interpreting studies]
Creators Name:Bollschweiler, E. and Schneider, P.M. and Moenig, S.P. and Altendorf-Hofmann, A. and Mansmann, U. and Lehmacher, W. and Schlag, P.M. and Merkel, S. and Hohenberger, W. and Izbicki, J.R. and Hermanek, P. and Hoelscher, A.H.
Abstract:Experts on different specialities (surgery, pathology, molecular biology and medical statistics) discussed the evaluation of prognostic factors during a workshop. The most important results presented are: (1) the prognostic relevance of new biological or molecular markers must be evaluated in a phase-III prognostic study. To establish such a marker in the UICC-TNM-classification in at least two different centers, two multivariate analyses according to defined criteria are necessary; (2) the standards of laboratory methods have to be defined, e.g.,which method to apply for RNA-analysis, which materials to used, etc; (3) intensive data analysis should be done before using methods of multivariate analysis. The criteria for the presentation of survival curves are given in detail; (4) in multivariate analysis, the Cox proportional hazard regression for survival outcomes is discussed with explanations and examples of the terms relative risk, odds-ratio, hazard and relative hazard. The arrangement and interpretation of a good prognostic study should be performed as an interdisciplinary approach.
Keywords:Prognosis, Biological Marker, Molecular Marker, TNM-Classification, Univariate Analysis, Multivariate Analysis
Source:Chirurg
ISSN:0009-4722
Publisher:Springer (Germany)
Volume:74
Number:2
Page Range:139-144
Date:February 2003
Official Publication:https://doi.org/10.1007/s00104-002-0557-7
PubMed:View item in PubMed

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