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Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster

Item Type:Article
Title:Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster
Creators Name:Zdobnov, E.M. and von Mering, C. and Letunic, I. and Torrents, D. and Suyama, M. and Copley, R.R. and Christophides, G.K. and Thomasova, D. and Holt, R.A. and Subramanian, G.M. and Mueller, H.M. and Dimopoulos, G. and Law, J.H. and Wells, M.A. and Birney, E. and Charlab, R. and Halpern, A.L. and Kokoza, E. and Kraft, C.L. and Lai, Z. and Lewis, S. and Louis, C. and Barillas-Mury, C. and Nusskern, D. and Rubin, G.M. and Salzberg, S.L. and Sutton, G.G. and Topalis, P. and Wides, R. and Wincker, P. and Yandell, M. and Collins, F.H. and Ribeiro, J. and Gelbart, W.M. and Kafatos, F.C. and Bork, P.
Abstract:Comparison of the genomes and proteomes of the two diptera Anopheles gambiae and Drosophila melanogaster, which diverged about 250 million years ago, reveals considerable similarities. However, numerous differences are also observed; some of these must reflect the selection and subsequent adaptation associated with different ecologies and life strategies. Almost half of the genes in both genomes are interpreted as orthologs and show an average sequence identity of about 56%, which is slightly lower than that observed between the orthologs of the pufferfish and human (diverged about 450 million years ago). This indicates that these two insects diverged considerably faster than vertebrates. Aligned sequences reveal that orthologous genes have retained only half of their intron/exon structure, indicating that intron gains or losses have occurred at a rate of about one per gene per 125 million years. Chromosomal arms exhibit significant remnants of homology between the two species, although only 34% of the genes colocalize in small "microsyntenic" clusters, and major interarm transfers as well as intra-arm shuffling of gene order are detected.
Keywords:Anopheles, Chromosome Inversion, Chromosomes, Cluster Analysis, Genetic Dosage Compensation, Drosophila Proteins, Drosophila melanogaster, Evolution, Exons, Gene Order, Insect Genes, Genome, Insect Proteins, Introns, Physical Chromosome Mapping, Tertiary Protein Structure, Proteome, Pseudogenes, Nucleic Acid Sequence Homology, Species Specificity, Synteny, Animals
Source:Science
ISSN:0036-8075
Publisher:American Association for the Advancement of Science (U.S.A.)
Volume:298
Number:5591
Page Range:149-159
Date:4 October 2002
Official Publication:https://doi.org/10.1126/science.1077061
PubMed:View item in PubMed

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