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Initial sequencing and comparative analysis of the mouse genome

Item Type:Review
Title:Initial sequencing and comparative analysis of the mouse genome
Creators Name:Waterston, R.H. and Lindblad-Toh, K. and Birney, E. and Rogers, J. and Abril, J.F. and Agarwal, P. and Agarwala, R. and Ainscough, R. and Alexandersson, M. and An, P. and Antonarakis, S.E. and Attwood, J. and Baertsch, R. and Bailey, J. and Barlow, K. and Beck, S. and Berry, E. and Birren, B. and Bloom, T. and Bork, P. and Botcherby, M. and Bray, N. and Brent, M.R. and Brown, D.G. and Brown, S.D. and Bult, C. and Burton, J. and Butler, J. and Campbell, R.D. and Carninci, P. and Cawley, S. and Chiaromonte, F. and Chinwalla, A.T. and Church, D.M. and Clamp, M. and Clee, C. and Collins, F.S. and Cook, L.L. and Copley, R.R. and Coulson, A. and Couronne, O. and Cuff, J. and Curwen, V. and Cutts, T. and Daly, M. and David, R. and Davies, J. and Delehaunty, K.D. and Deri, J. and Dermitzakis, E.T. and Dewey, C. and Dickens, N.J. and Diekhans, M. and Dodge, S. and Dubchak, I. and Dunn, D.M. and Eddy, S.R. and Elnitski, L. and Emes, R.D. and Eswara, P. and Eyras, E. and Felsenfeld, A. and Fewell, G.A. and Flicek, P. and Foley, K. and Frankel, W.N. and Fulton, L.A. and Fulton, R.S. and Furey, T.S. and Gage, D. and Gibbs, R.A. and Glusman, G. and Gnerre, S. and Goldman, N. and Goodstadt, L. and Grafham, D. and Graves, T.A. and Green, E.D. and Gregory, S. and Guigo, R. and Guyer, M. and Hardison, R.C. and Haussler, D. and Hayashizaki, Y. and Hillier, L.W. and Hinrichs, A. and Hlavina, W. and Holzer, T. and Hsu, F. and Hua, A. and Hubbard, T. and Hunt, A. and Jackson, I. and Jaffe, D.B. and Johnson, L.S. and Jones, M. and Jones, T.A. and Joy, A. and Kamal, M. and Karlsson, E.K. and Karolchik, D. and Kasprzyk, A. and Kawai, J. and Keibler, E. and Kells, C. and Kent, W.J. and Kirby, A. and Kolbe, D.L. and Korf, I. and Kucherlapati, R.S. and Kulbokas, E.J. and Kulp, D. and Landers, T. and Leger, J.P. and Leonard, S. and Letunic, I. and LeVine, R. and Li, J. and Li, M. and Lloyd, C. and Lucas, S. and Ma, B. and Maglott, D.R. and Mardis, E.R. and Matthews, L. and Mauceli, E. and Mayer, J.H. and McCarthy, M. and McCombie, W.R. and McLaren, S. and McLay, K. and McPherson, J.D. and Meldrim, J. and Meredith, B. and Mesirov, J.P. and Miller, W. and Miner, T.L. and Mongin, E. and Montgomery, K.T. and Morgan, M. and Mott, R. and Mullikin, J.C. and Muzny, D.M. and Nash, W.E. and Nelson, J.O. and Nhan, M.N. and Nicol, R. and Ning, Z. and Nusbaum, C. and O'Connor, M.J. and Okazaki, Y. and Oliver, K. and Overton-Larty, E. and Pachter, L. and Parra, G. and Pepin, K.H. and Peterson, J. and Pevzner, P. and Plumb, R. and Pohl, C.S. and Poliakov, A. and Ponce, T.C. and Ponting, C.P. and Potter, S. and Quail, M. and Reymond, A. and Roe, B.A. and Roskin, K.M. and Rubin, E.M. and Rust, A.G. and Santos, R. and Sapojnikov, V. and Schultz, B. and Schultz, J. and Schwartz, M.S. and Schwartz, S. and Scott, C. and Seaman, S. and Searle, S. and Sharpe, T. and Sheridan, A. and Shownkeen, R. and Sims, S. and Singer, J.B. and Slater, G. and Smit, A. and Smith, D.R. and Spencer, B. and Stabenau, A. and Stange-Thomann, N. and Sugnet, C. and Suyama, M. and Tesler, G. and Thompson, J. and Torrents, D. and Trevaskis, E. and Tromp, J. and Ucla, C. and Ureta-Vidal, A. and Vinson, J.P. and von Niederhausern, A.C. and Wade, C.M. and Wall, M. and Weber, R.J. and Weiss, R.B. and Wendl, M.C. and West, A.P. and Wetterstrand, K. and Wheeler, R. and Whelan, S. and Wierzbowski, J. and Willey, D. and Williams, S. and Wilson, R.K. and Winter, E. and Worley, K.C. and Wyman, D. and Yang, S. and Yang, S.P. and Zdobnov, E.M. and Zody, M.C. and Lander, E.S.
Abstract:The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
Keywords:Base Composition, Mammalian Chromosomes, Conserved Sequence, CpG Islands, Molecular Evolution, Gene Expression Regulation, Genes, Genetic Variation, Genome, Human Genome, Genomics, Animal Models, Multigene Family, Mutagenesis, Neoplasms, Physical Chromosome Mapping, Proteome, Pseudogenes, Quantitative Trait Loci, Untranslated RNA, Nucleic Acid Repetitive Sequences, Genetic Selection, DNA Sequence Analysis, Sex Chromosomes, Species Specificity, Synteny, Animals, Mice
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:420
Number:6915
Page Range:520-562
Date:5 December 2002
Official Publication:https://doi.org/10.1038/nature01262
PubMed:View item in PubMed

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