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Comparative assessment of large-scale data sets of protein-protein interactions

Item Type:Article
Title:Comparative assessment of large-scale data sets of protein-protein interactions
Creators Name:von Mering, C. and Krause, R. and Snel, B. and Cornell, M. and Oliver, S.G. and Fields, S. and Bork, P.
Abstract:Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.
Keywords:Bias (Epidemiology), Factual Databases, False Positive Reactions, Fungal Proteins, Mass Spectrometry, Protein Binding, Proteins, Messenger RNA, Reference Standards, Sensitivity and Specificity, Two-Hybrid System Techniques
Publisher:Nature Publishing Group (U.K.)
Page Range:399-403
Date:23 May 2002
Official Publication:https://doi.org/10.1038/nature750
PubMed:View item in PubMed

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