Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population

Item Type:	Article
Title:	Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population
Creators Name:	Sander, T. and Ostapowicz, A. and Samochowiec, J. and Smolka, M. and Rommelspacher, H. and Winterer, G. and Schmidt, L.G.
Abstract:	Our study tested whether an association of the 861C allele of the serotonin 5-HT1B gene (HTR1B) with antisocial alcoholism exists in the German population. The HTR1B G861C polymorphism was genotyped in 588 subjects of German descent, comprising 250 non-alcoholic controls and 338 alcohol-dependent subjects, of whom 56 exhibited a dissocial personality disorder (DSPD). The Tridimensional Personality Questionnaire was assessed in 109 alcohol-dependent males to explore an effect of the 861C allele to risk-taking behaviour. Our results revealed no evidence for an association of the 861C allele with antisocial alcoholism (p > 0.63). There were no significant differences in the personality traits, novelty-seeking, harm avoidance and reward dependence between 46 male alcoholics carrying the 861C allele compared to those 63 alcoholics lacking it (p > 0.52). Our results do not provide evidence that the 861C allele contributes a substantial vulnerability effect to antisocial behavior in German alcohol-dependent subjects.
Source:	Addiction Biology
ISSN:	1355-6215
Volume:	5
Number:	2
Page Range:	167-172
Date:	April 2000
Official Publication:	https://doi.org/10.1080/13556210050003757
PubMed:	View item in PubMed

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