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Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence

Item Type:Article
Title:Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence
Creators Name:Gscheidel, N. and Sander, T. and Wendel, B. and Heere, P. and Schmidt, L.G. and Rommelspacher, H. and Hoehe, M.R. and Samochowiec, J.
Abstract:The human {my} opioid receptor (hMOR) gene is a prime candidate gene responsible for addictive disorders. The present association study tested the hypothesis that hMOR exon 1 variants elicit susceptibility to alcohol dependence. We have analyzed five nucleotide changes in exon 1 of the hMOR gene. Three of them are in the 5′ untranslated region of exon 1 at positions -172G/T, -111C/T and -38C/A, the remaining two variants cause amino acid substitutions: + 17C/T (Ala6Val) and + 118A/G (Asn40Asp). Our population-based association study included 327 German alcohol-dependent subjects and 340 ethnically matched controls. The lack of an allelic association suggests that the analyzed hMOR exon 1 variants do not contribute a common and substantial effect to the genetically determined vulnerability of alcohol dependence.
Keywords:Alcohol Dependence, hMOR, {My} Opioid Receptor, Association, Genetics
Source:Polish Journal of Pharmacology
Publisher:Polish Acad Sciences Inst Pharmacology
Page Range:27-31
Date:January 2000
Official Publication:http://if-pan.krakow.pl/pjp/001_3.htm
PubMed:View item in PubMed

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