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Transcriptional profiling identifies Id2 function in dendritic cell development

Official URL:https://doi.org/10.1038/ni903
PubMed:View item in PubMed
Creators Name:Hacker, C. and Kirsch, R.D. and Ju, X.S. and Hieronymus, T. and Gust, T.C. and Kuhl, C. and Jorgas, T. and Kurz, S.M. and Rose-John, S. and Yokota, Y. and Zenke, M.
Journal Title:Nature Immunology
Journal Abbreviation:Nat Immunol
Volume:4
Number:4
Page Range:380-386
Date:April 2003
Keywords:B-Lymphocytes, Cell Differentiation, DNA-Binding Proteins, Dendritic Cells, Gene Expression Profiling, Inhibitor of Differentiation Protein 2, Oligonucleotide Array Sequence Analysis, Granulocyte-Macrophage Colony-Stimulating Factor Receptors, Interleukin-4 Receptors, Repressor Proteins, Transcription Factors, Transforming Growth Factor beta, Up-Regulation
Abstract:Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2-/- mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8alpha+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-beta also lack LCs, and we demonstrate here that, in DCs, TGF-beta induces Id2 expression. We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors.
ISSN:1529-2908
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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