Helmholtz Gemeinschaft


Establishing a structural genomics platform: The Berlin-based Protein Structure Factory

Item Type:Review
Title:Establishing a structural genomics platform: The Berlin-based Protein Structure Factory
Creators Name:Heinemann, U.
Abstract:Structural genomics (structural proteomics) initiatives aiming at the systematic, genome-directed structure analysis of proteins have recently been established in many locations worldwide. As a common international research endeavor, these initiatives thrive at the determination of protein structures representing all sequence families known in the biosphere. To reach this goal, a degree of international coordination of the structural genomics effort, as well as the development of high-throughput structure analysis methods and the provision of suitable research facilities are required. The Protein Structure Factory is a local, Berlin-based structural genomics project aiming at the structure determination of human proteins of presumed structural novelty and medical relevance. This project employs both NMR spectroscopy and X-ray crystallography for protein structure determination and aims at developing automated or semi-automated procedures for protein expression cloning and purification, and NMR spectral assignments. In addition, protein crystallography facilities are being set up at the third-generation synchrotron storage ring BESSY II in Berlin.
Keywords:Structural Genomics/Proteomics, Protein Structure Analysis, High-Throughput, NMR Spectroscopy, X-ray Crystallography
Source:Gene Function and Disease
Page Range:25-32
Date:October 2002
Official Publication:https://doi.org/10.1002/1438-826X(200210)3:1/2<25::AID-GNFD25>3.0.CO;2-W

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