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Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

Item Type:Article
Title:Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
Creators Name:Podar, K. and Tai, Y.T. and Davies, F.E. and Lentzsch, S. and Sattler, M. and Hideshima, T. and Lin, B.K. and Gupta, D. and Shima, Y. and Chauhan, D. and Mitsiades, C. and Raje, N. and Richardson, P. and Anderson, K.C.
Abstract:Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.
Keywords:Cell Division, Cell Movement, Endothelial Growth Factors, Extracellular Matrix Proteins, Flavonoids, Gene Expression, Plasma Cell Leukemia, Lymphokines, MAP Kinase Kinase 1, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Multiple Myeloma, Protein Kinase C, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-raf, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Cultured Tumor Cells, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors
Source:Blood
ISSN:0006-4971
Publisher:American Society of Hematology (U.S.A.)
Volume:98
Number:2
Page Range:428-435
Date:15 July 2001
Official Publication:https://doi.org/10.1182/blood.V98.2.428
PubMed:View item in PubMed

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