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Identification of attenuation and antitermination regulation in prokaryotes

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Item Type:Article
Title:Identification of attenuation and antitermination regulation in prokaryotes
Creators Name:Lathe, W.C. and Suyama, M. and Bork, P.
Abstract:Many operons of biochemical pathways in bacterial genomes are regulated by processes called attenuation and antitermination. Though the specific mechanism can be quite different, attenuation and antitermination in these operons have in common the termination of transcription by a RNA 'terminator' fold upstream of the first gene in the operon. In the past, detecting regulation by attenuation or antitermination has often been a long process of experimental trial and error, on a case by case basis. We report here the prediction of over 290 upstream regions of genes with attenuation or antitermination regulation structures in the completed genomes of Bacillis subtilis and Escherichia coli for which extensive experimental studies have been done on attenuation and antitermination regulation. These predictions are based on a computational method devised from characteristics of known terminator fold candidates and benchmark regions of entire genomes. We extend this methodology to 24 additional complete genomes and are thus able to give a more complete picture of attenuation and antitermination regulation in bacteria.
Source:Genome Biology
Publisher:BioMed Central
Page Range:preprint0003.1
Date:30 April 2002
Official Publication:https://doi.org/10.1186/gb-2002-3-6-preprint0003

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