Helmholtz Gemeinschaft


Chemotherapy response and resistance

Official URL:https://doi.org/10.1016/S0959-437X(02)00014-X
PubMed:View item in PubMed
Creators Name:Lee, S. and Schmitt, C.A.
Journal Title:Current Opinion in Genetics & Development
Journal Abbreviation:Curr Opin Dev
Page Range:90-96
Date:February 2003
Keywords:Neoplasm Drug Resistance, Neoplasms, Oncogenes
Abstract:Apoptosis and premature senescence, an acutely inducible terminal cell-cycle arrest, are known to be the ultimate cellular defense programs that counteract oncogenic transformation. Thus, activated oncogenes may sensitize cells to other stimuli that also recruit these programs. Recent evidence demonstrates that both apoptosis and premature senescence respond to drugs and can therefore contribute to the outcome of cancer therapy. However, manifest malignancies may have acquired mutations that compromise these programs at different levels, and hence may become chemoresistant to varying degrees as a result of defects in either or both programs.
Item Type:Review

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