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Nitric oxide synthase 2Lambarene (G-954C), increased nitric oxide production, and protection against malaria

Item Type:Article
Title:Nitric oxide synthase 2Lambarene (G-954C), increased nitric oxide production, and protection against malaria
Creators Name:Kun, J.F. and Mordmueller, B. and Perkins, D.J. and May, J. and Mercereau-Puijalon, O. and Alpers, M. and Weinberg, J.B. and Kremsner, P.G.
Abstract:A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambarene) (NOS2‐G954C), protects heterozygous carriers against severe malaria as effectively as the sickle cell trait. In a prospective longitudinal study, 841 individual infections of initially 200 children (151 wild‐type vs. 49 NOS2(Lambarene) carriers) were monitored for 4 years, to assess the rates of malarial attacks in the 2 groups; carriers of the NOS2(Lambarene) polymorphism were significantly less likely to experience malarial attacks than were others (P=.002). The distribution of the NOS2(Lambarene) polymorphism was investigated in malaria‐endemic areas. It was found to be present with the highest frequency in Africa and at a lower frequency in Asia. Ex vivo studies showed that cells isolated from people with this polymorphism have a 7‐fold higher baseline NOS activity, compared with the levels detected in cells from subjects with the wild‐type gene (P=.003).
Keywords:Case-Control Studies, DNA, Gabon, Gene Frequency, Germany, Heterozygote Detection, Innate Immunity, Malaria, Nigeria, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Papua New Guinea, Point Mutation, Polymerase Chain Reaction, Senegal, Single Nucleotide Polymorphism, Thailand
Source:Journal of Infectious Diseases
Page Range:330-336
Date:1 August 2001
Official Publication:https://doi.org/10.1086/322037
PubMed:View item in PubMed

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