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Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models

Item Type:Article
Title:Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models
Creators Name:Bader, M.
Abstract:M. Bader. Role of the Local Renin–angiotensin System in Cardiac Damage: a Minireview Focussing on Transgenic Animal Models. Journal of Molecular and Cellular Cardiology (2002) 34, 1455–1462. The local generation of all components of the renin-angiotensin system (RAS) in the heart has been the basis for the postulation of a tissue RAS in this organ. Since angiotensin II is involved in the induction of cardiac hypertrophy and fibrosis the local generation of this peptide may be of highest clinical importance. Several transgenic animal models have been generated to evaluate the functional importance of the cardiac RAS. We have established a new hypertensive mouse model lacking local angiotensinogen expression in the heart. In these animals, cardiac weight and collagen synthesis are increased compared to normotensive control mice but to a lesser extent than in mice with equally enhanced blood pressure but intact cardiac angiotensinogen generation. Thus, we have shown that local synthesis of this protein is involved but not essential in the development of cardiac hypertrophy and fibrosis.
Keywords:Transgenic Animals, Renin-Angiotensin System, Renin, Angiotensinogen, Angiotensin-Converting Enzyme,, Angiotensin Receptors, Cardiac Fibrosis, Cardiac Hypertrophy, Animals, Mice, Rats
Source:Journal of Molecular and Cellular Cardiology
ISSN:0022-2828
Publisher:Elsevier (The Netherlands)
Volume:34
Number:11
Page Range:1455-1462
Date:November 2002
Official Publication:https://doi.org/10.1006/jmcc.2002.2077
PubMed:View item in PubMed

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