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A role for Neuregulin1 signaling in muscle spindle differentiation

Item Type:Article
Title:A role for Neuregulin1 signaling in muscle spindle differentiation
Creators Name:Hippenmeyer, S. and Shneider, N.A. and Birchmeier, C. and Burden, S.J. and Jessell, T.M. and Arber, S.
Abstract:The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction.
Keywords:Afferent Neurons, Cell Differentiation, Developmental Gene Expression Regulation, DNA-Binding Proteins, Early Growth Response Protein 3, Fetus, Knockout Mice, Motor Neurons, Muscle Spindles, Skeletal Muscle, Mutation, Neuregulin-1, Proprioception, Protein Isoforms, Signal Transduction, Spinal Ganglia, Transcription Factors, Animals, Mice
Publisher:Cell Press (U.S.A.)
Page Range:1035-1049
Date:19 December 2002
Official Publication:https://doi.org/10.1016/S0896-6273(02)01101-7
PubMed:View item in PubMed

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