Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension

Item Type:	Article
Title:	Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension
Creators Name:	Sharma, A.M. and Golay, A.
Abstract:	Objective : To investigate the effects of long-term weight management with orlistat on blood pressure in obese hypertensive patients. Design : A meta-analysis of data from five multicenter, randomized, placebo-controlled studies, conducted in Europe and the USA, was performed. Patients : Obese adults [body mass index (BMI) 28–43 kg/m2] with uncontrolled diastolic hypertension or isolated systolic hypertension (ISH) were eligible for inclusion. Interventions : Following a 4-week placebo lead-in period, patients were randomized to orlistat 120 mg or placebo three times daily, in conjunction with a mildly reduced calorie diet for 1 year. Main outcome measures : Change in body weight was the primary efficacy parameter. Blood pressure, heart rate and systolic workload were assessed as secondary efficacy parameters. Results : A total of 628 patients were included in the intent-to-treat (ITT) analysis. After 56 weeks, orlistat-treated patients had lost significantly more body weight than placebo recipients (8.0 versus 4.0%;P< 0.001). Among patients with ISH, mean systolic pressure was reduced to a significantly greater degree after 1 year with orlistat compared to placebo (−9.4 versus −4.6 mmHg;P = 0.022). Similarly, reductions in mean diastolic pressure in patients with diastolic hypertension were greater with orlistat than with placebo (−7.7 versus −5.6 mmHg;P = 0.017). Weight loss of ≥ 10% was associated with significant reductions in blood pressure, heart rate and systolic workload. Conclusions : Orlistat promotes clinically meaningful weight loss that is associated with significant reductions in blood pressure and heart rate, and may therefore have a role in the management of hypertension in overweight and obese patients.
Keywords:	Obesity, Weight Loss, Hypertension, Orlistat, Heart Rate, Systolic Workload
Source:	Journal of Hypertension
ISSN:	0263-6352
Publisher:	Lippincott Williams & Wilkins
Volume:	20
Number:	9
Page Range:	1873-1878
Date:	September 2002
Official Publication:	https://doi.org/10.1097/00004872-200209000-00034
PubMed:	View item in PubMed

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