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Hip1 and Hippi participate in a novel cell death-signaling pathway

Official URL:https://doi.org/10.1016/S1534-5807(02)00121-1
PubMed:View item in PubMed
Creators Name:Wanker, E.E.
Journal Title:Developmental Cell
Journal Abbreviation:Dev Cell
Volume:2
Number:2
Page Range:126-128
Date:February 2002
Keywords:Apoptosis, Caspases, DNA-Binding Proteins, Huntington Disease, Signal Transduction
Abstract:Neuronal apoptosis is a cardinal feature of late-onset neurodegenerative disorders such as Alzheimers and Huntington's disease. Biochemical and cell biological studies point to a role for Hip1 and Hippi in caspase-8 activation and the initiation of apoptosis during the pathogenesis of Huntington's disease.
ISSN:1534-5807
Publisher:Cell Press (U.S.A.)
Item Type:Editorial

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