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β2 adrenergic receptor gene variations and coping styles in twins

Item Type:Article
Title:β2 adrenergic receptor gene variations and coping styles in twins
Creators Name:Busjahn, A. and Freier, K. and Faulhaber, H.D. and Li, G.H. and Rosenthal, M. and Jordan, J. and Hoehe, M.R. and Timmermann, B. and Luft, F.C.
Abstract:We tested the hypothesis that the {beta}-2 adrenergic receptor ({beta}-2 AR) gene locus, with known effects on blood pressure regulation, is also involved in psychological coping styles. 166 pairs of monozygotic (MZ) and dizygotic (DZ) twins and DZ twin parents were investigated. We found common genetic variance for the coping factor Emotional Coping and blood pressure. Using three microsatellites we found linkage between the {beta}-2 AR gene locus and the coping factor Active Coping. Using allele-specific PCR of all the single nucleotide polymorphisms (SNPs) in the gene causing amino acid substitutions we identified associations between the +491 G/A SNP and various coping factors. We conclude that the {beta}-2 AR gene is relevant to coping. These preliminary findings suggest a molecular genetic underpinning of the relationship between psychological and physiological phenotypes important to cardiovascular risk.
Keywords:Coping, Genetics, Environment, Twins
Source:Biological Psychology
ISSN:0301-0511
Volume:61
Number:1-2
Page Range:97-109
Date:October 2002
Official Publication:https://doi.org/10.1016/S0301-0511(02)00054-6
PubMed:View item in PubMed

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