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Naive CD8+ but not CD4+ T cells induce maturation of dendritic cells

Item Type:Article
Title:Naive CD8+ but not CD4+ T cells induce maturation of dendritic cells
Creators Name:Schueler, T. and Blankenstein, T.
Abstract:We have shown previously that the generation of tumor-reactive CD8+ cytotoxic T lymphocytes require qualitatively different signals from CD4+ and CD8+ T cells that most likely are provided to dendritic cells (DCs). This raises the question of whether the two T cell subsets are equally able to deliver the initial activation signal to DCs. Using ovalbumin as a model antigen we show that naive CD4+ T cells cannot activate immature DCs and do not become activated, even though they recognize antigen on immature DCs. In contrast, naive CD8+ T cells rapidly activate DCs and subsequently start to proliferate. This suggests that CD8+ T cells contribute to DC activation prior to CD4+ T cells and implies that CD8+ T cells can provide help to CD4+ T cells.
Keywords:Dendritic Cells, Antigen, Presentation/Processing, T Lymphocytes, Cellular Activation, Cellular Differentiation, Animals, Mice
Source:Journal of Molecular Medicine
Page Range:533-541
Date:August 2002
Official Publication:https://doi.org/10.1007/s00109-002-0360-4
PubMed:View item in PubMed

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